RF9 hydrochloride 是一种有效且有选择性的神经肽 FF 受体 (Neuropeptide FF receptor) 拮抗剂 ，对于 hNPFF1R 和 hNPFF2R 的 Ki 值分别为 58 和 7 nM。
货号:ajcx29654
CAS:N/A
分子式:C26H39ClN6O3
分子量：519.08
溶解度:DMSO: 50 mg/mL (96.32 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

RF9 hydrochloride is a potent and selective Neuropeptide FF receptor antagonist, with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively[1][2].

RF9 (10 μM) pretrement completely blocks NPFF induced neurite outgrowth of Neuro 2A cells[2].

RF9 (0.1 mg/kg, s.c. ) with heroin coadministration prevents heroin-induced delayed hyperalgesia and tolerance[1].RF9 (10 μg) infused alone does not result in a significant alteration of MAP or heart rate. Conversely, MAP and heart rate increases evoked by NPFF are significantly blocked when NPFF is applied in conjunction with RF9[1]. Animal Model: Rats[1]

[1]. Simonin F, et al. RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia. Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):466-71. [2]. Ting Zhang, et al. Discovery of Two Novel Branched Peptidomimetics Containing endomorphin-2 and RF9 Pharmacophores: Synthesis and Neuropharmacological Evaluation. Bioorg Med Chem. 2019 Feb 15;27(4):630-643.