A2793是有效的TWIK相关酸敏感K+通道1(TASK-1)的抑制剂，其IC50值为6.8μM。
货号:ajcx30086
CAS:88349-90-0
分子式:C13H12ClNO3
分子量：265.69
溶解度:DMSO: 100 mg/mL (376.38 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

A2793 is an efficient TWIK-related acid-sensitive K+ channel (TASK)-1 inhibitor, with an IC50 of 6.8 μM[1].

A2793 (100 µM) inhibits the unstimulated channel by 43.0±8.9% (n=5) while after ionomycin activation the reduction of the TRESK current is 85.5±2.9% (n=5)[1].A2793 may be considered as a tool to discriminate between the resting and activated channels in heterologous expression systems, and to block TRESK activated by calcineurin in the native cells which do not express TASK-1[1].

[1]. MiklÓs Lengyel, et al. Chemically Modified Derivatives of the Activator Compound Cloxyquin Exert Inhibitory Effect on TRESK (K 2P 18.1) Background Potassium Channel. Mol Pharmacol. 2019 Jun;95(6):652-660.