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2'-Deoxy-2'-fluorocytidine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
2'-Deoxy-2'-fluorocytidine图片
包装:100mg
规格:98%
市场价:445元
分子量:245.21

产品介绍
2'-Deoxy-2'-fluorocytidine是一种核苷类似物,是刚果出血热病毒(CCHFV)复制的有效抑制剂。2'-Deoxy-2'-fluorocytidine可与T705协同作用,增强两种化合物对CCHFV复制的抗病毒效力。
货号:ajcx32394
CAS:10212-20-1
分子式:C9H12FN3O4
分子量:245.21
溶解度:H2O: 5 mg/mL (20.39 mM; ultrasonic and warming and heat to 60°C)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

2'-Deoxy-2'-fluorocytidine, an nucleoside analog, is a potent inhibitor of Crimean-Congo hemorrhagic fever virus (CCHFV) replication. 2′-deoxy-2′-fluorocytidine can act synergistically with T705 to increase the potency of both compounds antiviral effects on CCHFV replication[1].

2'-Deoxy-2'-fluorocytidine has antiviral activities, showing 50% effective concentrations (EC50) of 61 nM and 31 nM against CCHFV and CCHFV/ZsG in Huh7 cells, respectively. And it shows a 50% cytotoxicity concentration (CC50) of >50.0 μM in Huh7 cells[1].


[1]. Stephen R Welch, et al. Identification of 2'-deoxy-2'-fluorocytidine as a potent inhibitor of Crimean-Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus. Antiviral Res. 2017 Nov;147:91-99.