GRL-0496 是一种有效的氯吡啶酯衍生的 SARS-CoV 3CLpro 抑制剂，IC50 值为 30 nM。GRL-0496 显示出最佳的 SARS-CoV 抗病毒活性，EC50 值为 6.9 μM。
货号:ajcx33294
CAS:1087243-14-8
分子式:C14H9ClN2O2
分子量：272.69
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

GRL-0496 is a potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitor, with an IC50 of 30 nM in both enzyme inhibitory and antiviral assays. GRL-0496 shows SARS-CoV antiviral activity, with an EC50 of 6.9 μM[1].

GRL-0496 shows the best SARS-CoV antiviral activity, with an EC EC50 of 6.9 μM[1].

[1]. Ghosh AK, et, al. Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5684-8.