2-Methylquinazolin-4-ol 是一种高效、竞争性的 poly(ADP-ribose) synthetase 抑制剂，其 Ki 值为 1.1 μM。2-Methylquinazolin-4-ol 是哺乳动物天冬氨酸氨基转移酶 (ATCase) 抑制剂，其 IC50 值为 0.20 mM。
货号:ajcx34400
CAS:1769-24-0
分子式:C9H8N2O
分子量：160.17
溶解度:DMSO : 50 mg/mL (312.17 mM; Need ultrasonic)|H2O :< 0.1 mg/mL (insoluble)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

2-Methylquinazolin-4-ol is a potent competitive poly(ADP-ribose) synthetase inhibitor, with a Ki of 1.1 μM. 2-Methylquinazolin-4-ol mammalian aspartate transcarbamylase (ATCase) inhibitor, with 0.20 mM[1][2].

2-Methylquinazolin-4-ol inhibits ATCase in a concentration-dependent manner[1].

2-Methylquinazolin-4-ol (0.2-1 mg; i.g.; for two days) inhibits ATCase in a dosedependent manner in vivo[2].

[1]. S Yoshida, et al. Production of 2-methyl-4[3H]-quinazolinone, an inhibitor of poly(ADP-ribose) synthetase, by bacterium. J Antibiot (Tokyo). 1991 Jan;44(1):111-2.
[2]. Mahmoud Balbaa, et al. Inhibition of mammalian aspartate transcarbamylase by quinazolinone derivatives. J Enzyme Inhib Med Chem. 2008 Aug;23(4):483-92.