TH5427 是一种很有前途的靶向抑制剂，可用于进一步研究 NUDT5 活性和 ADP-核糖代谢。TH5427 阻断孕激素依赖性、PAR 衍生的核 ATP 合成以及随后的乳腺癌细胞染色质重塑、基因调控和增殖。NUDT5 最近被确定为乳腺癌细胞激素依赖性基因调控和增殖的变阻器。
货号:ajcx38160
CAS:2253744-56-6
分子式:C20H20Cl2N8O3
分子量：491.33
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

TH5427 is a promising, targeted inhibitor that can be used to further study NUDT5 activity and ADP-ribose metabolism. TH5427, blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells. NUDT5 is recently identified as a rheostat of hormone-dependent gene regulation and proliferation in breast cancer cells[1].

[1]. Page BDG, et al. Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells [published correction appears in Nat Commun. 2019 Nov 1;10(1):5050]. Nat Commun. 2018;9(1):250.