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Azido-PEG6-amine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Azido-PEG6-amine图片
规格:98%
分子量:350.41
包装与价格:
包装价格(元)
50mg电议
100mg电议
200mg电议
500mg电议

产品介绍
Azido-PEG6-amine 是一种 PROTAC linker,属于 PEG 类,可用于合成 PROTAC 分子。Azido-PEG6-amine 也是一种不可降解 (non-cleavable) 的含 6 个单元 PEG 的 ADC linker,可用于合成抗体偶联药物 (ADC)。
货号:ajcx38344
CAS:957486-82-7
分子式:C14H30N4O6
分子量:350.41
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Azido-PEG6-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG6-amine is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].

[1]. Williams EGL, et al. Glycosylated Reversible Addition-Fragmentation Chain Transfer Polymers with Varying Polyethylene Glycol Linkers Produce Different Short Interfering RNA Uptake, Gene Silencing, and Toxicity Profiles. Biomacromolecules. 2017 Dec 11;18(12):4099-4112.
[2]. Philip Wilson Howard, et al. Pyrrolobenzodiazepines and conjugates thereof. WO2014140862A2.