规格: | 98% |
分子量: | 350.41 |
包装 | 价格(元) |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
Background:
Azido-PEG6-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG6-amine is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
[1]. Williams EGL, et al. Glycosylated Reversible Addition-Fragmentation Chain Transfer Polymers with Varying Polyethylene Glycol Linkers Produce Different Short Interfering RNA Uptake, Gene Silencing, and Toxicity Profiles. Biomacromolecules. 2017 Dec 11;18(12):4099-4112.
[2]. Philip Wilson Howard, et al. Pyrrolobenzodiazepines and conjugates thereof. WO2014140862A2.