KIF18A-IN-3 是一种有效的 KIF18A 抑制剂 (IC50=61 nM)。KIF18A-IN-3 能引起明显的有丝分裂停滞，增加肿瘤组织中有丝分裂细胞的数量。KIF18A-IN-3 可用于肿瘤研究。
货号:ajcx38432
CAS:2600577-49-7
分子式:C28H38N4O5S2
分子量：574.76
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

KIF18A-IN-3 is a potent KIF18A inhibitor (IC50=61 nM). KIF18A-IN-3 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-3 can be used for researching cancer[1].

KIF18A-IN-3 (compound 24) exhibits a significant and sustained pharmacodynamic response, increasing the number of mitotic cells (pH3 positive cells) in tumor tissues for up to 24 hours[1].Pharmacokinetic Parameters of KIF18A-IN-3 in female CD-1 mice[1]. IP (100 mg/kg) C_{max (μM)26.5AUC0-24 (μM.h)269 C24h (μM)0.8PPB (fu)0.015}

[1]. Tamayo NA, et al. Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe. J Med Chem. 2022;65(6):4972-4990.