您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > SW-100
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
SW-100
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SW-100图片
规格:98%
分子量:316.78
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
SW-100 是一种有效的组蛋白脱乙酰基酶 6 (HDAC6) 抑制剂,IC50 值为 2.3 nM,相对于其他 HDAC 酶,对 HDAC6 的选择性至少高 1000倍。SW-100 显著提高了跨越血脑屏障的能力。
货号:ajcx38654
CAS:2126744-35-0
分子式:C17H17ClN2O2
分子量:316.78
溶解度:DMSO : ≥ 125 mg/mL (394.60 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

SW-100, a selective histone deacetylase 6 (HDAC6) inhibitor with an IC50 of 2.3 nM, shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays a significantly improved ability to cross the blood-brain-barrier[1].

SW-100 (0.01-10 µM; 48 hours) shows obvious increase in the acetylated α-tubulin levels in a dose-dependent manner[1].

SW-100 (20 mg/kg; i.p.; twice a day for two days) ameliorates several memory and learning impairments including novel object recognition, temporal ordering, and coordinate and categorical spatial processing in mouse model of Fragile X syndrome[1].

[1]. Kozikowski AP, et al. Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and LearningImpairments in a Mouse Model of Fragile X Syndrome. ACS Chem Neurosci. 2019 Mar 20;10(3):1679-1695.

Protocol:

HDAC1

5.23μM(IC50)

HDAC2

32.8μM(IC50)

HDAC3

29.5μM(IC50)

HDAC4

10.9μM(IC50)

HDAC5

4.07μM(IC50)

HDAC6

2.3nM(IC50)

HDAC7

4.55μM(IC50)

HDAC8

3.72μM(IC50)

HDAC9

3.46μM(IC50)

HDAC10

26.2μM(IC50)

HDAC11

5.72μM(IC50)