规格: | 98% |
分子量: | 316.78 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
Background:
SW-100, a selective histone deacetylase 6 (HDAC6) inhibitor with an IC50 of 2.3 nM, shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays a significantly improved ability to cross the blood-brain-barrier[1].
SW-100 (0.01-10 µM; 48 hours) shows obvious increase in the acetylated α-tubulin levels in a dose-dependent manner[1].
SW-100 (20 mg/kg; i.p.; twice a day for two days) ameliorates several memory and learning impairments including novel object recognition, temporal ordering, and coordinate and categorical spatial processing in mouse model of Fragile X syndrome[1].
[1]. Kozikowski AP, et al. Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and LearningImpairments in a Mouse Model of Fragile X Syndrome. ACS Chem Neurosci. 2019 Mar 20;10(3):1679-1695.
Protocol:
HDAC1 5.23μM(IC50) | HDAC2 32.8μM(IC50) | HDAC3 29.5μM(IC50) | HDAC4 10.9μM(IC50) | HDAC5 4.07μM(IC50) | HDAC6 2.3nM(IC50) | HDAC7 4.55μM(IC50) | HDAC8 3.72μM(IC50) | HDAC9 3.46μM(IC50) | HDAC10 26.2μM(IC50) | HDAC11 5.72μM(IC50) |