BSJ-03-123是由Cereblon配体和CDK配体相连的PROTAC，是有效，新颖的CDK6选择性的小分子降解剂。
货号:ajcx38970
CAS:2361493-16-3
分子式:C47H56N10O11
分子量：937.01
溶解度:DMSO : 100 mg/mL (106.72 mM; ultrasonic and adjust pH to 3 with HCl)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

BSJ-03-123 is a PROTAC connected by ligands for Cereblon and CDK as a potent and novel CDK6-selective small-molecule degrader.

BSJ-03-123 (BSJ) causes a pronounced anti-proliferative effect in CDK6-dependent AML cell lines by inducing a G1 cell-cycle arrest without a measurable increase in apoptosis[1].

[1]. Brand M, et al. Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML. Cell Chem Biol. 2019 Feb 21;26(2):300-306.e9.