TK05 是一种有效选择性的白三烯 C4 合成酶 (LTC4S) 抑制剂，其 IC50 值为 95 nM。
货号:ajcx39582
CAS:1245734-61-5
分子式:C31H25ClN2O5
分子量：540.99
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

TK05 is a potent and selective inhibitor of leukotriene C4 synthase (LTC4S) with an IC50 of 95 nM[1].

TK05 reduces LTC4 production in a dose-dependent manner with an IC50 value of 318 ± 60 nM in MM6 Cells[1].

TK05 (0.12-6 mg/kg; given i.p.; only once) significantly reduces LTE4 levels[1].

[1]. Kleinschmidt TK, et al. Tandem Benzophenone Amino Pyridines, Potent and Selective Inhibitors of Human Leukotriene C4 Synthase. J Pharmacol Exp Ther. 2015 Oct;355(1):108-16.