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Afabicin(Debio 1450)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Afabicin(Debio 1450)图片
规格:98%
分子量:485.43
包装与价格:
包装价格(元)
250mg电议
500mg电议

产品介绍
Afabicin(Debio1450)是Debio1452的前体药物,能够抵抗葡萄球菌staphylococci,但对其他的革兰氏阳性菌和阴性菌没有明显作用。Debio1452是FabI抑制剂,能够抑制葡萄球菌中的脂肪合成。
货号:ajcx12772
CAS:1518800-35-5
分子式:C23H24N3O7P
分子量:485.43
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Afabicin (Debio 1450) is the prodrug of Debio1452, specifically targeting staphylococci without significant activity against other Gram-positive or Gram-negative species. Debio1452 is an inhibitor FabI, an enzyme critical to fatty acid biosynthesis in staphylococci.

Afabicin (Debio1450) is the prodrug of Debio1452, specifically targeting staphylococci without significant activity against other Gram-positive or Gram-negative species. Debio1452 inhibits FabI, an enzyme critical to fatty acid biosynthesis in staphylococci. Debio1452 is highly active against staphylococci isolates, with MIC50 and MIC90 values of 0.015 μg/mL and 0.12 μg/mL, respectively. Debio1452 also inhibits S. aureus, with MICs of ≤0.12 μg/mL and MIC50 and MIC90 values of 0.004 μg/mL and 0.008 μg/mL, respectively[1].


[1]. Flamm RK, et al. Activity of Debio1452, a FabI inhibitor with potent activity against Staphylococcus aureus and coagulase-negative Staphylococcus spp., including multidrug-resistant strains. Antimicrob Agents Chemother. 2015 May;59(5):2583-7.