BIO-11006 acetate salt，MANS 肽的类似物，是一种 myristoylated alanine-rich C kinase substrate (MARCKS) 抑制剂。
货号:ajcx13758
CAS:N/A
分子式:C48H79N13O17
分子量：1110.22
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

BIO-11006 acetate salt, an analog of the MANS peptide, is a myristoylated alanine-rich C kinase substrate (MARCKS) inhibitor[1]. Myristoylated alanine-rich C kinase substrate[1]

Inhaled, aerosolized BIO-11006 attenuates LPS-induced neutrophil influx into the lung, activation of NF-κB, and expression of the proinflammatory cytokines, KC and TNF-α, and thus reverses the development of lung injury in mice instilled intratracheally with LPS[1].

[1]. Yin Q, et al. An Inhaled Inhibitor of Myristoylated Alanine-Rich C Kinase Substrate Reverses LPS-Induced Acute Lung Injury in Mice. Am J Respir Cell Mol Biol. 2016 Nov;55(5):617-622.