Cysteine Thiol Probe 是一种基于硫醇的探针，旨在标记亲电子的天然产物。Cysteine Thiol Probe 具有理想药效团探针的每个特征，并具有发色团。Cysteine Thiol Probe 能够结合基于烯酮，β-内酰胺和 β-内酯的亲电子代谢物。
货号:ajcx16286
CAS:1947408-74-3
分子式:C11H12BrNO3S
分子量：318.19
溶解度:DMSO: 250 mg/mL (785.69 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Cysteine Thiol Probe is a thiol-based probe designed to label electrophilic natural products. Cysteine Thiol Probe possesses each of the characteristics of an ideal pharmacophore probe, and has a chromophore. Cysteine Thiol Probe is capable of engaging enone-, β-lactam-, and β-lactone-based electrophilic metabolites[1][2].

[1]. Castro-FalcÓn G, et al. Thiol Probes To Detect Electrophilic Natural Products Based on Their Mechanism of Action. ACS Chem Biol. 2016 Aug 19;11(8):2328-36. [2]. Reimer D, et al. Thiol-Based Probe for Electrophilic Natural Products Reveals That Most of the Ammosamides Are Artifacts. J Nat Prod. 2017 Jan 27;80(1):126-133.