Dihydromunduletone (DHM) 是类胡萝卜素衍生物，是一种选择性，有效的粘附 G 蛋白偶联受体 (aGPCR) (GPR56 and GPR114/ADGRG5) 拮抗剂，对 GPR56 的 IC 50 值为 20.9 μM，但不抑制 GPR110 或 A 类 GPCR。
货号:ajcx16512
CAS:674786-20-0
分子式:C25H28O6
分子量：424.49
溶解度:DMSO: 250 mg/mL (588.94 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Dihydromunduletone (DHM) is a rotenoid derivative and a selective, potent adhesion G protein-coupled receptor (aGPCR) (GPR56 and GPR114/ADGRG5) antagonist with an IC 50 of 20.9 μM for GPR56, but not inhibit GPR110 or class A GPCRs[1].

[1]. Hannah M. Stoveken, et al. Dihydromunduletone Is a Small-Molecule Selective Adhesion G Protein-Coupled Receptor Antagonist. Mol Pharmacol. 2016 Sep; 90(3): 214-224.