IHVR-19029 是一种有效的内质网 α-葡萄糖苷酶 Ⅰ 和 Ⅱ (α-glucosidases I/II) 抑制剂，对 ER α-葡萄糖苷酶 Ⅰ 的 IC50 为0.48 μM。IHVR-19029 能有效阻断几种出血热病毒的复制，如登革病毒、埃博拉病毒和裂谷热病毒。
货号:ajcx16726
CAS:1447464-73-4
分子式:C23H45N3O5
分子量：443.62
溶解度:DMSO: 250 mg/mL (563.55 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

IHVR-19029 is a potent endoplasmic reticulum (ER) α-glucosidases I and II inhibitor, with an IC50 of 0.48 μM for ER a-glucosidase I. IHVR-19029 efficiently blocks the replication of several hemorrhagic fever viruses, such as Dengue virus (DENV), Ebola virus (EBOV) and Rift Valley fever virus[1][2][3].

[1]. Bray M, et al. Meeting report: 31st International Conference on Antiviral Research. Antiviral Res. 2018 Oct;158:88-102. [2]. Jin hong Chang, et al. Small molecule inhibitors of ER α-glucosidases are active against multiple hemorrhagic fever viruses. Antiviral Research. Volume 98, Issue 3, June 2013, Pages 432-440. [3]. Ester Prodrugs of IHVR-19029 with Enhanced Oral Exposure and Prevention of Gastrointestinal Glucosidase Interaction.ACS Med Chem Lett. 2017 Jan 17;8(2):157-162. [4]. Ma J, et al. Enhancing the antiviral potency of ER α-glucosidase inhibitor IHVR-19029 against hemorrhagic fever viruses in vitro and in vivo. Antiviral Res. 2018 Feb;150:112-122.