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Citrulline-specific Probe-Rhodamine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Citrulline-specific Probe-Rhodamine图片
规格:98%
分子量:731.8
包装与价格:
包装价格(元)
250ug电议
500ug电议
1mg电议

产品介绍
Protein arginine deiminases (PADs) catalyze the posttranslational modification of arginine residues on proteins to form citrulline, which plays a large role in regulating gene expression.
货号:ajcx18270
CAS:2309313-01-5
分子式:C39H35N7O7•H2O
分子量:731.8
溶解度:Acetonitrile:Water (2:1): 1 mg/ml,DMF: 1 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Protein arginine deiminases (PADs) catalyze the posttranslational modification of arginine residues on proteins to form citrulline, which plays a large role in regulating gene expression. Abnormally high PAD activity has been observed in a host of human diseases. Citrulline-specific probe-rhodamine is a highly sensitive, rhodamine phenylglyoxal-based fluorophore that specifically detects protein citrullination via a chemoselective reaction between glyoxal and citrulline. This chemical probe (comprised of a single isomer) is capable of reacting with any citrulline-containing protein and can be analyzed with fluorescent imaging (excitation 532 nm; emission 580 nm). When added at 100 µM for 30 minutes at acidic pH, this probe has a reported limit of detection of ~10 ng for citrullinated histone H3 and ~1 ng for autodeiminated PAD4.