The phosphatidylinositol phosphates represent a small percentage of total membrane phospholipids.
货号:ajcx18938
CAS:N/A
分子式:C41H78O19P3•3NH4
分子量：1022.1
溶解度:50 mM HEPES*: 8 mg/ml,CHCl3:CH3OH:H2O (3:2:1): 10 mg/ml,PBS (pH 7.2): 1 mg/ml (opaque solution)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

The phosphatidylinositol phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(4,5)-P2 incorporated into membrane lipids can bind to important proteins such as Group IV cPLA2 and PLCδ1, enhancing their adherence to the membrane and increasing the rate of substrate hydrolysis. PtdIns-(4,5)-P2 can be further phosphorylated to give triphosphates such as PtdIns-(3,4,5)-P3. It can also be cleaved by PI-specific PLC to give inositol triphosphates. The diacyl glycerol and IP3 generated by this PLC-cleavage are also part of a complex biochemical and signal transduction cascade which has not been entirely elucidated. For some additional reading, please see references , , and .