Pitstop2 is an inhibitor of the interaction between the clathrin terminal domain and amphiphysin
货号:ajcx19586
CAS:1332879-52-3
分子式:C20H13BrN2O3S2
分子量：473.4
溶解度:20mg/mL in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Pitstop2 is an inhibitor of the interaction between the clathrin terminal domain and amphiphysin (IC50 = 12 μM).1 It inhibits clathrin-mediated transferrin uptake in HeLa and U2OS cells (IC50s = 12-15 and 9.7 μM, respectively). Pitstop2 inhibits HIV-1 entry and infectivity in HeLa reporter cell lines. It also inhibits clathrin-independent endocytosis of CD44, CD98, and CD147 in HeLa cells.2

参考文献
1. von Kleist, L., Stahlschmidt, W., Bulut, H., et al. Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition. Cell 146(3), 471-484 (2012).
2. Dutta, D., Williamson, C.D., Cole, N.B., et al. Pitstop 2 is a potent inhibitor of clathrin-independent endocytosis. PLoS One 7(9), e45799 (2012).