A neuropeptide with diverse biological activities
货号:ajcx20842
CAS:N/A
分子式:C18H30D4O4
分子量：318.5
溶解度:DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml,PBS (pH 7.2): 10 μg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

(±)9(10)-DiHOME-d₄is intended for use as an internal standard for the quantification of (±)9(10)-DiHOME by GC- or LC-MS. (±)9(10)-DiHOME is the diol form of (±)9(10)-EpOME , a cytochrome P450-derived epoxide of linoleic acid also known as leukotoxin.¹It is formed from 9(10)-EpOME by soluble epoxide hydrolase (sEH) in neutrophils.²9(10)-DiHOME has been used as a plasma biomarker for sEH activityin vivo.³It is toxic to Sf21 cells expressing sEH and tolacZ-expressing control cells, unlike leukotoxin, which is only toxic to cells containing sEH.^1,2A mixture of 9(10)- and 12(13)-DiHOME induces cell death in rabbit renal proximal tubule cells concomitant with mitochondrial respiration dysfunction and induces lung injury, respiratory distress, and mortality in mice.^4,59(10)-DiHOME is a toxic lipid mediator involved in acute respiratory distress syndrome (ARDs), a common and often fatal complication in severe burn victims.^2,4Levels of 9(10)-DiHOME are increased in bronchoalveolar lavage fluid (BALF) from women, but not men, with chronic obstructive pulmonary disease (COPD).³BALF levels are also increased in patients with allergic asthma following provocation with birch pollen compared to patients without allergic asthma.⁶

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