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[Sar9,Met(O2)11]-Substance P(trifluoroacetate salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
[Sar9,Met(O2)11]-Substance P(trifluoroacetate salt)图片
包装:1mg
规格:98%
市场价:2678元
分子量:1393.7

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx20974
CAS:N/A
分子式:C64H100N18O15S.XCF3COOH
分子量:1393.7
溶解度:Water: 1 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

[Sar9, Met(O2)11]-Substance P (Sar-SP) is a peptide agonist of the neurokinin-1 (NK1) receptor.1It is selective for NK1over NK2and NK3receptors. Sar-SP induces inositol phosphate formation in U373MG glioblastoma cells with an EC50value of 3.8 nM, an effect that can be blocked by the NK1receptor antagonist SR 140333.2It induces contractions in isolated human bronchi when used at concentrations of 3, 100, and 1,000 nM.3Sar-SP (10, 25, 65, and 100 pmol/animal, i.c.v.) increases mean arterial pressure and heart rate in conscious rats.4


1.Regoli, D., Drapeau, G., Dion, S., et al.New selective agonists for neurokinin receptors: pharmacological tools for receptor characterizationTrends Pharmacol. Sci.9(8)290-295(1988) 2.Oury-Donat, F., Thurneyssen, L.O., Gauthier, T., et al.SR 1140333, a novel, selective, and potent nonpeptide antagonist of the NKl tachykinin receptor: Characterization on the U373MG cell lineJ. Neurochem.62(4)1399-1407(1994) 3.Barchasz, E., Naline, E., Molimard, M., et al.Interleukin-1β-induced hyperresponsiveness to Sar9,Met(O2)11 substance x 2 P in isolated human bronchiEur. J. Pharmacol.379(1)87-95(1999) 4.Cellier, E., Barbot, L., Iyengar, S., et al.Characterization of central and peripheral effects of septide with the use of five tachykinin NK1 receptor antagonists in the ratBr. J. Pharmacol.127(3)717-728(1999)