A neuropeptide with diverse biological activities
货号:ajcx21098
CAS:N/A
分子式:C20H30O5D4
分子量：358.5
溶解度:DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,PBS: 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

13,14-dihydro-15-keto Prostaglandin E₁-d₄(13,14-dh-15-k PGE₁-d₄) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 13,14-dh-15-k PGE₁by GC-or LC-mass spectrometry. 13,14-dh-15-k PGE₁is a metabolite of PGE₁with much reduced biological activity.^1,2,3Steady state plasma concentrations are about 10 pg/ml.¹13,14-dh-15-k PGE₁is a weak inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets with IC₅₀values of 54 and 200 µM, respectively, compared to PGE₁which has an IC₅₀value of 40 nM.⁴

1.Leonhardt, A., Krauss, M., Gieler, U., et al.In vivo formation of prostaglandin E1 and prostaglandin E2 in atopic dermatitisBr. J. Dermatol.136(3)337-340(1997) 2.Hamberg, M., and Samuelsson, B.On the metabolism of prostaglandins E1 and E2 in manJ. Biol. Chem.246(22)6713-6721(1971) 3.Peskar, B.A., Cawello, W., Rogatti, W., et al.On the metabolism of prostaglandin E1 administered intravenously to human volunteersJournal of Physiology and Pharmacology42327-331(1991) 4.Kobzar, G., Mardla, V., JÄrving, I., et al.Antiaggregating potency of E-type prostaglandins in human and rabbit plateletsProceedings of the Estonian Academy of Sciences.Chemistry40179-180(1991)