An HMG-CoA reductase inhibitor
货号:ajcx21738
CAS:357164-38-6
分子式:C33H34FN2O5.1/2Ca [XH2O]
分子量：577.7
溶解度:DMF: 25 mg/ml,DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml,DMSO: 15 mg/ml,Ethanol: 0.5 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Atorvastatin is an inhibitor of HMG-CoA reductase, the rate-limiting enzyme in the mevalonate pathway of cholesterol synthesis, that has IC₅₀values of 73, 102, and 0.6 nM for HepG2 cells, human fibroblasts, and rat hepatocytes, respectively.¹Formulations containing atorvastatin have been used in the treatment of hypercholesterolemia and certain dyslipidemias.

1.Shaw, M.K., Newton, R.S., Sliskovic, D.R., et al.Hep-G2 cells and primary rat hepatocytes differ in their response to inhibitors of HMG-CoA reductaseBiochem. Biophys. Res. Commun.170(2)726-734(1990)