| 规格: | 98% |
| 分子量: | 753 |
| 包装 | 价格(元) |
| 500ug | 电议 |
| 1mg | 电议 |
Background:
Azithromycin-13C-d3is intended for use as an internal standard for the quantification of azithromycin by GC- or LC-MS. Azithromycin is a macrolide antibiotic.1It is active againstS. pneumoniae,S. aureus,N. gonorrhoeae,M. pneumoniae,H. pylori,C. trachomatis, andH. influenzae in vitro(MIC90s =<0.01-2 mg/L). Azithromycin increases survival in mouse models of intraperitonealS. pyogenes,S. pneumoniae,E. faecalis, orH. influenzaeinfection (ED50s = 0.78, 8.7, 12.7, and 30.3 mg/kg, respectively).2It also decreases plasma levels of IL-6, TNF-α, and IL-1β and increases survival in mouse model of LPS-induced sepsis when administered at a dose of 100 mg/kg.3Formulations containing azithromycin have been used in the treatment of a variety of bacterial infections.
1.Kanatani, M.S., and Guglielmo, B.J.The new macrolides. Azithromycin and clarithromycinWestern J. Med.160(1)31-37(1994) 2.Girard, D., Finegan, S.M., Dunne, M.W., et al.Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection modelsJ. Antimicrob. Chemother.56(2)365-371(2005) 3.Patel, A., Joseph, J., Periasamy, H., et al.Azithromycin in combination with ceftriaxone reduces systemic inflammation and provides survival benefit in a murine model of polymicrobial sepsisAntimicrob. Agents Chemother.62(9)e00752-00718(2018)
m.cnreagent.com