A neuropeptide with diverse biological activities
货号:ajcx21914
CAS:N/A
分子式:C67H117D3N3O26.NH4
分子量：1404.7
溶解度:Chloroform:Methanol:Water (2:1:0.1): Soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

C18 Ganglioside G_M2-d₃is intended for use as an internal standard for the quantification of ganglioside G_M2by GC- or LC-MS. C18 Ganglioside G_M2is a monosialylated ganglioside found in the mammalian brain where it is localized to the cell membrane.¹It accumulates in Tay-Sachs and Sandhoff disease, which are neurodegenerative disorders characterized by deficiency of lysosomal β-hexosaminidase A and B, respectively.²Ganglioside G_M2disrupts the function of immune cells and, when used at a concentration of 25 µM, increases migration and invasion of SK-RC-45 cells with no effect on proliferation.³[Matreya, LLC. Catalog No. 2051]

1.Schnaar, R.L.Gangliosides of the vertebrate nervous systemJ. Mol. Biol.428(16)3325-3336(2016) 2.Baek, R.C., Martin, D.R., Cox, N.R., et al.Comparative analysis of brain lipids in mice, cats, and humans with Sandhoff diseaseLipids44(3)197-205(2009) 3.Kundu, M., Mahata, B., Banerjee, A., et al.Ganglioside GM2 mediates migration of tumor cells by interacting with integrin and modulating the downstream signaling pathwayBiochim. Biophys. Acta.1863(7 Pt A)1472-1489(2016)