您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Doripenem-d4(sodium salt)
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Doripenem-d4(sodium salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Doripenem-d4(sodium salt)图片
规格:98%
分子量:446.5
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx22364
CAS:N/A
分子式:C15H19D4N4O6S2.Na
分子量:446.5
溶解度:Water: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Doripenem-d4is intended for use as an internal standard for the quantification of doripenem by GC- or LC-MS. Doripenem is a broad-spectrum antibiotic in the β-lactam subclass known as carbapenems.1,2It is active against Gram-negative and Gram-positive bacteria, includingS. aureus,S. pneumoniae,E. coli, andK. pneumoniae(MICs = 0.03-0.06, 0.016-0.06,<0.015-0.3, and 0.03-0.06 µg/ml, respectively).1,2,3,4Doripenem reduces the number of viable bacteria in mouse lung in a model of chronicP. aeruginosarespiratory tract infection when administered at a dose of 100 mg/kg per day.5It inhibits bacterial cell wall synthesis by forming stable acyl enzymes with penicillin-binding proteins, thereby inactivating them.2Formulations containing doripenem have been used in the treatment of bacterial infections.


1.Mandell, L.Doripenem: A new carbapenem in the treatment of nosocomial infectionClin. Infect. Dis.49(Suppl 1)S1-S3(2009) 2.Paterson, D.L., and DePestel, D.D.DoripenemClin. Infect. Dis.49(2)291-298(2009) 3.Papp-Wallace, K.M., Endimiani, A., Taracila, M.A., et al.Carbapenems: Past, present, and futureAntimicrob. Agents Chemother.55(11)4943-4960(2011) 4.El Solh, A.A., and Alhajhusain, A.Update on the treatment of Pseudomonas aeruginosa pneumoniaJ. Antimicrob. Chemother.64(2)229-238(2009) 5.Araki, N., Yanagihara, K., Morinaga, Y., et al.In vivo efficacy of doripenem (DRPM) against Pseudomonas aeruginosa in murine chronic respiratory tract infection modelJ. Infect. Chemother.17(3)318-321(2011)