A neuropeptide with diverse biological activities
货号:ajcx22372
CAS:N/A
分子式:C18[13C]H18D3NO.HCl
分子量：319.9
溶解度:DMSO: soluble,Methanol: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Doxepin-¹³C-d₃is intended for use as an internal standard for the quantification of doxepin by GC- or LC-MS. Doxepin is a tricyclic antidepressant that binds to the serotonin (5-HT) transporter (SERT) and norepinephrine transporter (NET; K_ds = 68 and 29.5 nM, respectively).¹It is a histamine H₁receptor antagonist (K_i= 1.23 nM).²Doxepin selectively binds to SERT and NET over the dopamine transporter (DAT; K_d= 12,100 nM) and inhibits histamine H₁over H₂, H₃, and H₄receptors (K_is = 170, 39,810, and 15,135 nM, respectively).^1,2It also binds to the 5-HT₂receptor, as well as to muscarinic acetylcholine and α₁-adrenergic receptors (α₁-ARs; K_ds = 27, 23, and 23.5 nM, respectively).³Doxepin (10 mg/kg, i.p.) decreases allodynia and hyperalgesia in a mouse model of chronic constriction injury-induced neuropathic pain.⁴It increases the distance traveled in the center of the open field test and reduces immobility time in the forced swim test in a mouse model of depression induced by chronic stress when administered orally at a dose of 15 mg/kg.⁵Formulations containing doxepin have been used in the treatment of depression and insomnia.

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