An internal standard for the quantification of hydroxyzine
货号:ajcx22646
CAS:1808202-93-8
分子式:C21H19ClD8N2O2.2HCl
分子量：455.9
溶解度:Water: slightly soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Hydroxyzine-d₈is intended for use as an internal standard for the quantification of hydroxyzine by GC- or LC-MS. Hydroxyzine is a histamine H₁receptor antagonist (K_i= 1.9 nM).¹It binds competitively with the H₁receptor inverse agonist mepyramine with an IC₅₀value of 80 µM in polymorphonuclear leukocytes.²In vivo, it is metabolized to the H₁receptor antagonist cetirizine .³In situ, hydroxyzine (10 µM) prevents recruitment of rolling leukocytes induced by histamine in rat mesentery post-capillary venules.⁴Hydroxyzine also decreases anxiety-like behavior in mice, increasing the time spent in the open arms of the elevated plus maze and in the light side of the light-dark exploration test.⁵Formulations containing hydroxyzine have been used in the treatment of anxiety and as antihistamines in the treatment of allergic rhinitis.

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