An inhibitor of SARS-CoV-2 Mpro
货号:ajcx22998
CAS:2413716-71-7
分子式:C25H25FN4O4
分子量：464.5
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

M^Proinhibitor 11b is an inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (M^Pro; IC₅₀= 0.04 µM in a TR-FRET assay).¹It reduces viral yield in the culture supernatant of SARS-CoV-2-infected Vero E6 cells (EC₅₀= 0.72 µM). M^Proinhibitor 11b also reduces viral RNA copy numbers in the same model when used at concentrations ranging from 1.85 to 50 µM.

1.Dai, W., Zhang, B., Jiang, X.-M., et al.Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main proteaseScience368(6497)1331-1335(2020)