An internal standard for the quantification of nafcillin
货号:ajcx24198
CAS:1356354-25-0
分子式:C21H16D5N2O5S•Na
分子量：441.5
溶解度:DMSO: slightly soluble,Methanol: slightly soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Nafcillin-d₅is intended for use as an internal standard for the quantification of nafcillin by GC- or LC-MS. Nafcillin is a semisynthetic and penicillinase-resistant penicillin antibiotic.¹It is active against 20 clinical isolates ofS. aureuswith minimum bactericidal concentration (MBC) values ranging from 0.078 to 0.312 µg/ml. Nafcillin (100-800 mg/kg) reduces the number of kidney colony forming units (CFUs) in a mouse model ofS. aureusinfection.²It also reduces the number of right atrial CFUs in a rabbit model ofS. aureus-induced endocarditis.³Formulations containing nafcillin have been used in the treatment of various bacterial infections.

1.Tuazon, C.U., Lin, M.Y., and Sheagren, J.N.In vitro activity of rifampin alone and in combination with nafcillin and vancomycin against pathogenic strains of Staphylococcus aureusAntimicrob. Agents Chemother.13(5)759-761(1978) 2.Yuchenco, J.A., Hopper, M.W., Vince, T.D., et al.Nafcillin and oxacillin: Comparative antistaphylococcal activity in miceJ. Antibiot. (Tokyo)29(4)460-465(1976) 3.Carrizosa, J., Kobasa, W.D., and Kaye, D.Effectiveness of nafcillin, methicillin, and cephalothin in experimental Staphylococcus aureus endocarditisAntimicrob. Agents Chemother.15(5)735-737(1979)