| 规格: | 98% |
| 分子量: | 380.5 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
Background:
Isonanangenine B is a drimane sesquiterpene lactone that has been found inAspergillus.1,2It decreases survivin mRNA expression in a reporter assay when used at concentrations of 13.6, 18.42, and 26.31 µM. Isonanagenine B (18.42 µM) inhibits STAT3 and NF-κB binding to the survivin promoter in chromatin immunoprecipitation (ChIP) assays. It also induces apoptosis in COLO 320DM cells.
1.Lacey, H.J., Gilchrist, C.L.M., Crombie, A., et al.Nanangenines: Drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, Aspergillus nanangensisBeilstein J. Org. Chem.152631-2643(2019) 2.Felix, S., Sandjo, L.P., Opatz, T., et al.SF002-96-1, a new drimane sesquiterpene lactone from an Aspergillus species, inhibits survivin expressionBeilstein J. Org. Chem.92866-2876(2013)
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