Background:

Aureonitol is a fungal metabolite that has been found inChaetomiumand has antiviral activity.¹It inhibits replication of the influenza A subtype H3N2 with an EC₅₀value of 30 nM at a multiplicity of infection (MOI) of 0.01. It also inhibits replication of laboratory-adapted and clinical isolates of H3N2 (EC₅₀s = 100 and 312 nM, respectively), as well as clinical isolates of the influenza A subtype H1N1 (EC₅₀= 417 nM). Aureonitol inhibits hemagglutination activity of H3N2 and H1N1.

1.Sacramento, C.Q., Marttorelli, A., Fintelman-Rodrigues, N., et al.Aureonitol, a fungi-derived tetrahydrofuran, inhibits influenza replication by targeting its surface glycoprotein hemagglutininPLoS One10(10)e0139236(2015)