SH-42 是一种有效的选择性人 Δ24-脱氢胆固醇还原酶 (DHCR24) 抑制剂，IC50 为 42 nM。
货号:ajcx25626
CAS:2143952-36-5
分子式:C25H38O4
分子量：402.6
溶解度:Chloroform: 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SH-42 is an inhibitor of ?²⁴-dehydrocholesterol reductase (DHCR24; IC₅₀= 4.2 nM).¹It increases serum levels of desmosterol , the immediate precursor of cholesterol in the Bloch pathway, in mice when administered at a dose of 0.5 mg/animal per day. SH-42 increases levels of arachidonic acid and its metabolite prostaglandin E₂, as well as docosahexaenoic acid and its metabolites 19,20-EpDPA and 19,20-DiHDPA, in the peritoneal lavage fluid in a mouse model of peritonitis induced by zymosan A .²

1.MÜller, C., Hemmers, S., Bartl, N., et al.New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductaseEur. J. Med. Chem.140305-320(2017) 2.KÖrner, A., Zhou, E., MÜller, C., et al.Inhibition of δ24-dehydrocholesterol reductase activates pro-resolving lipid mediator biosynthesis and inflammation resolutionProc. Natl. Acad. Sci. USA116(41)20623-20634(2019)