Description: Novobiocin (also known as Albamycin; Cathomycin) is a novel and potent antibiotic of the aminocoumarinclass derived from Streptomyces niveus. It targets bacterial DNA gyrase (TopoIV),and is used to treat susceptible gram positive bacteria. Novobiocin also interacts with Hsp90, altering the affinity of the chaperone for geldanamycin and radicicol and causing in vitro and in vivo depletion of key regulatory Hsp90-dependent kinases including v-Src, Raf-1, and p185(ErbB2). Novobiocin interferes with association of the co-chaperones Hsc70 and p23 with Hsp90.

References: J Biol Chem. 2000 Nov 24;275(47):37181-6; Biochemistry. 2004 Jun 29;43(25):8217-29.

Related CAS#: 303-81-1 (Novobiocin; U 6391; U-6391; U6391); 4309-70-0 (Novobiocin calcium)

纯度：≥98%

CAS：303-81-1