An SGLT2 inhibitor and active metabolite of dapagliflozin
货号:ajcx26210
CAS:864070-37-1
分子式:C19H21ClO6
分子量：380.8
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

O-desethyl Dapagliflozin is an inhibitor of sodium-glucose cotransporter 2 (SGLT2; IC₅₀= 9.4 nM) and active metabolite of dapagliflozin .^1,2It is selective for SGLT2 over SGLT1 (IC₅₀= 970 nM).¹

1.Xu, B., Feng, Y., Cheng, H., et al.C-aryl glucosides substituted at the 4’-position as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetesBioorg. Med. Chem. Lett.21(15)4465-4470(2011) 2.Xu, G., Lv, B., Roberge, J.Y., et al.Design, synthesis, and biological evaluation of deuterated C-aryl glycoside as a potent and long-acting renal sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetesJ. Med. Chem.57(4)1236-1251(2014)