TRPC4/5 channel blocker; antidepressant and anxiolytic
货号:ajcx27242
CAS:N/A
分子式:C11H15N3.HCl
分子量：225.72
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

TRPC4/5 channel blocker (IC50 values are 3.7-10.3 and 8.2 μM, respectively). Also weakly blocks TRPC3 channels. Exhibits rapid antidepressant and anxiolytic effects in vivo.

Zhu et al (2015) Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels. Br.J.Pharmacol. 172 3495 PMID:25816897 |Yang et al (2015) Acute treatment with a novel TRPC4/C5 channel inhibitor produces antidepressant and anxiolytic-like effects in mice. PLoS One 10 e0136255 PMID:26317356