NS 383 是一种有效且独特的选择性大鼠 ASIC 抑制剂，含有 1a 和/或 3 个亚基。
货号:ajcx28030
CAS:309711-59-9
分子式:C19H19N3O2
分子量：321.37
溶解度:DMSO|1.61|5|
纯度：98%
存储：Store at -20°C
库存：现货

Background:

ASIC blocker (IC50 values are 0.44, 2.1 μM and no effect at rat ASIC1a, ASIC3 and ASIC2a, respectively: IC50 value = 0.12 μM at human ASIC1a with no effect at ASIC2a or ASIC3). Inhibition was also observed at heteromeric ASIC channels (IC50 values are 0.79, 0.87 and 4.5 uM at rat ASIC1a+3, ASIC1a+2a and ASIC2a+3; IC5O values are 0.33 and 0.69 uM at human ASIC1a+2a and ASIC1a+3, with no effect at ASIC2a+3). Attenuates pathophysiological nociceptive behaviors in CFA-inflamed and CCI rats.