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Relacatib(SB-462795 GSK-462795)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Relacatib(SB-462795 GSK-462795)图片
CAS NO:362505-84-8
规格:≥98%
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议

产品介绍

Relacatib (SB462795 and GSK462795) is a novel and orally bioavailable small molecule inhibitor of cathepsin K that inhibits bone resorption both in vitro in human tissue and in vivo in cynomolgus monkeys. SB-462795 is a potent inhibitor of human cathepsins K, L, and V (K(i, app)=41, 68, and 53 pM, respectively) that exhibits 39-300-fold selectivity over other cathepsins. SB-462795 inhibited endogenous cathepsin K in situ in human osteoclasts and human osteoclast-mediated bone resorption with IC50 of approximately 45 nM and approximately 70 nM, respectively.

纯度:≥98%

CAS:362505-84-8