L-NIO HCl is a non-selective inhibitor of all NOS isoforms. The Kis for nNOS (rat), eNOS (bovine), and iNOS (mouse) are 1.7, 3.9, and 3.9 μM, respectively. L-NIO inhibits endothelial-dependent relaxation induced by acetylcholine in rat aortic rings and hypotensive responses to acetylcholine and bradykinin. References: Muzaffar S, Jeremy JY, Angelini GD, Stuart-Smith K, Shukla N. Role of the endothelium and nitric oxide synthases in modulating superoxide formation induced by endotoxin and cytokines in porcine pulmonary arteries. Thorax. 2003 Jul;58(7):598-604. PubMed PMID: 12832676; PubMed Central PMCID: PMC1746752.

纯度：≥98%

CAS：36889-13-1