2′-O-(2-Methoxyethyl)guanosine (2'-O-MOE-rG) 是 2'-O-甲氧基乙基修饰的核苷，可以由 2′-O-(2-methoxyethyl)-2,6-diaminopurine riboside 酶促转化 (腺苷脱氨酶) 生成。2′-O-(2-Methoxyethyl)guanosine 不能被胞质核苷激酶有效地磷酸化，也不能被掺入细胞的 DNA 或 RNA 中。
货号:ajcx32744
CAS:473278-54-5
分子式:C13H19N5O6
分子量：341.32
溶解度:DMSO : 250 mg/mL (732.45 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

2′-O-(2-Methoxyethyl)guanosine (2'-O-MOE-rG), a 2′-O-methoxyethyl-modified nucleoside, can be produced by enzymatic conversion (adenosine deaminase) from 2′-O-(2-methoxyethyl)-2,6-diaminopurine riboside. 2′-O-(2-Methoxyethyl)guanosine neither effectively phosphorylated by cytosolic nucleoside kinases, nor are they incorporated into cellular DNA or RNA[1][2].

参考文献:
[1]. McPherson AK, et, al. An Improved Process for the Manufacture of 5′-O-(4,4′-Dimethoxytrityl)-N2-isobutyryl-2′-O-(2-methoxyethyl)guanosine. Org. Process Res. Dev. 2020, 24, 11, 2583-2590.
[2]. Saleh AF, et, al. 2'-O-(2-Methoxyethyl) Nucleosides Are Not Phosphorylated or Incorporated Into the Genome of Human Lymphoblastoid TK6 Cells. Toxicol Sci. 2018 May 1;163(1):70-78.