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Protein deglycase DJ-1 against-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Protein deglycase DJ-1 against-1图片
规格:98%
分子量:417.46
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Protein deglycase DJ-1 against-1 是 DJ-1 结合化合物,依赖地靶向 DJ1。Protein deglycase DJ-1 against-1 可以穿透血脑屏障 (BBB)。Protein deglycase DJ-1 against-1 是神经保护剂,具有用于帕金森病研究的潜力。
货号:ajcx32986
CAS:724737-74-0
分子式:C24H23N3O4
分子量:417.46
溶解度:DMSO : 25 mg/mL (59.89 mM; ultrasonic and adjust pH to 7 with NaOH)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Protein deglycase DJ-1 against-1, a DJ-1-binding compound, dependently targets DJ1. Protein deglycase DJ-1 against-1 penetrates through the blood brain barrier (BBB). Protein deglycase DJ-1 against-1 is used as a neuroprotective agent and has the potential for Parkinson’s disease research[1].


Protein deglycase DJ-1 against-1 (compound-23; 1 mg/kg; IP; pretreatment one hour; daily; for 4 days) significantly restores MPTP induced locomotion, dopaminergic neuronal cell death and dopamine content in DJ-1(+/+) mice but not in DJ-1(-/-) mice[1].

[1]. Kazuko Takahashi-Niki, et al. DJ-1-dependent protective activity of DJ-1-binding compound no. 23 against neuronal cell death in MPTP-treated mouse model of Parkinson’s disease.