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ACH-000143
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ACH-000143图片
规格:98%
分子量:297.74
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
ACH-000143 是有效的、具有口服活性的褪黑素受体的激动剂,对MT1 和MT2 的EC50 值分别为0.06 nM 和0.32 nM。
货号:ajcx34484
CAS:2225836-30-4
分子式:C13H16ClN3O3
分子量:297.74
溶解度:DMSO : 50 mg/mL (167.93 mM; Need ultrasonic)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

ACH-000143 is a potent and orally active melatonin receptor agonist, with EC50 values of 0.06 nM and 0.32 nM for MT1 and MT2, respectively[1].

ACH-000143 reduces liver triglycerides and steatosis in diet-Induced obese rats[1].ACH-000143 is devoid of hERG binding, genotoxicity, and behavioral alterations at doses up to 100 mg/kg p.o., supporting further investigation of this compound as a drug candidate[1].ACH-000143 significantly reduces plasma glucose at 10 mg/kg (-16.4%, p< 0.05) and 30 mg/kg (-16.9%, p< 0.01)[1].

[1]. Marcos Antonio Ferreira Jr, et al. Discovery of ACH-000143: A Novel Potent and Peripherally Preferred Melatonin Receptor Agonist that Reduces Liver Triglycerides and Steatosis in Diet-Induced Obese Rats. J Med Chem. 2021 Feb 25;64(4):1904-1929.