NF-κβ activator 2 是一种有效和具有口服活性的 NF-?B 激活剂，EC50 值为 1.58 μM。NF-κβ activator 2 通过增加 NF-κB 的表达和激活来诱导 SOD2。NF-κβ activator 2 可用于肌萎缩性侧索硬化症 (ALS) 的研究。
货号:ajcx35024
CAS:2375281-44-8
分子式:C16H11FN2O3
分子量：298.27
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

NF-κβ activator 2 is a potent and orally active NF-?B activator, with an EC50 of 1.58 μM. NF-κβ activator 2 induces SOD2 through increasing NF-?B expression and activation. NF-κβ activator 2 can be used for the research of amyotrophic lateral sclerosis (ALS)[1].

NF-κβ activator 2 (compound 61) (1 μM, 6 h) induces SOD2 mRNA expression in SH-SY5Y neuroblastoma cells[1].

NF-κβ activator 2 (1 mg/kg; i.v.) displays a suitable half-life (0.96 h) in mice[1].NF-κβ activator 2 (5 mg/kg; p.o.) displays a comparable half-life (2.86 h), oral bioavailability (15.6%), and Cmax (92 ng/mL)[1].

[1]. Mathew B, et, al. Structure-activity relationship (SAR) studies of N-(3-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (SRI-22819) as NF-?B activators for the treatment of ALS. Eur J Med Chem. 2020 Oct 22;112952.