PBP10 是一种甲酰基肽受体 2 (FPR2) 的细胞通透性和选择性的由 gelsolin 衍生的肽抑制剂，选择性优于对 FPR1 的。PBP10 是一种 N 端偶联罗丹明的10 个氨基酸的肽，对革兰氏阳性和革兰氏阴性菌具有杀菌活性，并且可以限制微生物诱导的炎症作用。
货号:ajcx36242
CAS:N/A
分子式:C86H128F3N24O17
分子量：1827.08
溶解度:H2O : 7.14 mg/mL (3.91 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

PBP10 is a cell permeable and selective gelsolin-derived peptide inhibitor of formyl peptide receptor 2 (FPR2) over FPR1[1]. PBP10 is a 10-AA peptide with rhodamine conjugated at its N terminus, exerts bactericidal activity against gram-positive and gram-negative bacteria and limits microbial-induced inflammatory effects[2].

[1]. Ewelina Piktel, et al. Inhibition of inflammatory response in human keratinocytes by magnetic nanoparticles functionalized with PBP10 peptide derived from the PIP2-binding site of human plasma gelsolin. J Nanobiotechnology. 2019 Feb 2;17(1):22.
[2]. C C Cunningham, et al.Cell permeant polyphosphoinositide-binding peptides that block cell motility and actin assembly. J Biol Chem