Propargyl-PEG5-NHS ester 是一种 PROTAC 连接桥，属于 PEG 类和 Alkyl/ether 类。Propargyl-PEG5-NHS ester 可用于合成一系列 PROTAC 分子。Propargyl-PEG5-NHS ester 是一种可降解 (cleavable) 的 ADC 连接桥，用于抗体药物结合物 (ADCs) 的合成。
货号:ajcx36450
CAS:1393330-40-9
分子式:C18H27NO9
分子量：401.41
溶解度:DMSO : 100 mg/mL (249.12 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Propargyl-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[1]. Zhenjun Diwu, et al. Polyfluoreno[4,5-cde]oxepine Conjugates and Their Use in Methods of Analyte Detection. US20170275418A1.