U-0521 是儿茶酚-O-甲基转移酶 (COMT) 的抑制剂。U-0521具有研究帕金森病的潜力。
货号:ajcx36638
CAS:5466-89-7
分子式:C10H12O3
分子量：180.2
溶解度:DMSO : 100 mg/mL (554.94 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

U-0521 is the inhibitor of the catechol-O-methyltransferase (COMT). U-0521 has the potential for the research of Parkinson’s disease[1].

U-0521 inhibits RBC COMT activity in a dose-dependent manner with an IC50 of 6 x10-6 M[1].

U-0521 (i.p.; 0-250 mg/kg; 10 min) inhibits COMT activity in a dose-dependent manner. 50% inhibition of enzyme activity is obtained at 90 mg/kg and maximum inhibition of 90% is obtained at 250 mg/kg[1].

[1]. Reches A, et al. Effect of 3’,4’-dihydroxy-2-methyl-propriophenone (U-0521) on catechol-O-methyltransferase activity and on DOPA accumulation in rat red blood cells and corpus striatum. Biochem Pharmacol. 1982;31(21):3415-3418.