N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline 是不可降解 (non-cleavable) 的 ADC linker，用于合成抗体偶联药物 (ADCs)。N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline 也是一个基于烷基链 (alkyl chain) 的 PROTAC linker，可用于合成 PROTAC。
货号:ajcx36952
CAS:147266-92-0
分子式:C10H17NO5
分子量：231.25
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.
[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.