Dirocaftor (PTI-808) 是一种 CFTR 增效剂，通过打开氯离子通道来增强 CFTR 蛋白的功能。Dirocaftor 可用于囊性纤维化 (CF) 的研究。
货号:ajcx37006
CAS:2137932-23-9
分子式:C22H28N2O3Si2
分子量：424.64
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Dirocaftor (PTI-808) is a CFTR potentiator that enhances the function of CFTR protein by opening chloride channels. Dirocaftor can be used for cystic fibrosis (CF) research[1][2].

When combined with Nesolicaftor and Posenacaftor, Dirocaftor can restore CFTR function to nearly normal levels[2].

[1]. James A Reihill, et al. Modulation of Ion Transport to Restore Airway Hydration in Cystic Fibrosis. Genes (Basel). 2021 Mar 22;12(3):453.
[2]. P. van Mourik, et al. WS10 Moving beyond body mass index to assess nutritional status in CF. Journal of Cystic Fibrosis 19S2 (2020) S1-S36.