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DDR1-IN-4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DDR1-IN-4图片
规格:98%
分子量:565.34
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
DDR1-IN-4 (Compound 2.45) 是有效、选择性的盘肽结构域受体 1 (DDR1) 自磷酸化的抑制剂,其对 DDR1 和 DDR2 的IC50 值分别为 29 nM 和 1.9 μM。
货号:ajcx37284
CAS:2125676-13-1
分子式:C23H20BrF3N6O3
分子量:565.34
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

DDR1-IN-4 (Compound 2.45) is a selective and potent Discoidin Domain Receptor 1 (DDR1) autophosphorylation inhibitor, with IC50 values of 29 nM and 1.9 μM for DDR1 and DDR2, respectively[1].

DDR1-IN-4 (Compound 2.45) shows a clear dose-dependent inhibition of DDR1 phosphorylation in HT1080 cells overexpressing DDR1, with greater than 70% inhibition of phosphorylation at a concentration of 1 μM, and retaining selectivity over inhibition of DDR2[1].

DDR1-IN-4 (Compound 2.45, ip, 90 mg/kg) preserves renal function and reduces tissue damage in Col4a3-/- mice (the preclinical mouse model of Alport syndrome) when employing a therapeutic dosing regime, indicating the real therapeutic value of selectively inhibiting DDR1 phosphorylation in vivo[1].

[1]. Hans Richter, et al. DNA-Encoded Library-Derived DDR1 Inhibitor Prevents Fibrosis and Renal Function Loss in a Genetic Mouse Model of Alport Syndrome. ACS Chem Biol. 2019 Jan 18;14(1):37-49.