PF-04745637 是一种有效的选择性 TRPA1 拮抗剂，对人 TRPA1 的 IC50 为 17 nM。
货号:ajcx37878
CAS:1917294-46-2
分子式:C27H32ClF3N2O2
分子量：509
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM for human TRPA1[1].

Topically applied PF-04745637 (Compound 8; 50 mg/mL and 100 mg/mL) significantly reduces cinnamaldehyde-mediated flare in rat skin[1].

[1]. Laurie B. Schenkel, et al. The discovery of a potent series of carboxamide TRPA1 antagonists. J. Med. Chem. 2016, 59, 6, 2794-2809.